Thermo Fisher Scientific TNIK Polyclonal Antibody
Rabbit polyclonal antibody targeting human TNIK (TRAF2 and NCK interacting kinase). Validated for WB and IP applications. Supplied as liquid, 1 mg/mL concentration. Recommended storage at 4°C. Predicted cross-reactivity with mouse TNIK.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 600 and 650 of Human TRAF2 and NCK interacting kinase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
TNIK (TRAF2 and NCK interacting kinase) is characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. TNIK is mainly expressed in brain, heart, and spleen, and acts as a specific effector of RAP2, regulating the actin cytoskeleton.
It is autophosphorylated in a lys54-dependent manner within the ATP-binding pocket of its kinase domain and plays a major role in cytoskeleton regulation. TNIK has also been shown to phosphorylate gelsolin, the principal actin-severing protein, suggesting a key role in cytoskeletal dynamics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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