Thermo Fisher Scientific RCAN2 Polyclonal Antibody
RCAN2 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat에서 반응하며, Protein A로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human RCAN2 (amino acids 1–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS (pH 7.4), with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus.
Isoform 1 is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest levels in brain, heart, and muscle.
Both isoforms bind to the catalytic subunit of calcineurin, a Ca²⁺-dependent protein phosphatase involved in neuronal functions, and inhibit its activity.
Unlike isoform 1, isoform 2 expression is not induced by thyroid hormone T3.
RCAN2 belongs to a family of three endogenous calcineurin regulators located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting a possible role in this syndrome.
Multiple isoforms of RCAN2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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