Thermo Fisher Scientific AMPK alpha-1,2 Polyclonal Antibody
AMPK alpha-1,2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용에 적합. 고순도(>95%) 및 항원 친화 크로마토그래피 정제. 세포 에너지 항상성 연구용으로 최적화.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 150–200 of human AMPK alpha1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553341 |
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 63 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK).
AMPK is a heterotrimer consisting of an alpha catalytic subunit and non-catalytic beta and gamma subunits.
It acts as an important energy-sensing enzyme that monitors cellular energy status.
In response to metabolic stresses, AMPK is activated and phosphorylates acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), key enzymes regulating fatty acid and cholesterol biosynthesis.
Studies in mice suggest that this catalytic subunit may control whole-body insulin sensitivity and is required for maintaining myocardial energy homeostasis during ischemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-36045_AMPK_alpha-1,2_P54646-1_Rabbit.svg / PA5-36045_AMPK_alpha-1,2_P54646-1_Rabbit_PDP.jpeg)
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