Thermo Fisher Scientific Protein Z Polyclonal Antibody
Rabbit polyclonal antibody recognizing human Protein Z. Validated for Western blot and IHC (paraffin). Supplied as liquid, 1 mg/mL, purified by Protein A. Suitable for coagulation-related protein studies. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Protein Z |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Protein Z (PROZ) is a vitamin K-dependent plasma glycoprotein of approximately 62 kDa, composed of 396 amino acids. It includes a gla-rich region, two EGF-like domains, and a trypsin-like domain but lacks the catalytic serine residue typical of serine proteases. Protein Z participates in the coagulation cascade, aiding in the regulation of blood clot formation. Its function depends on vitamin K, and activity may be affected by warfarin therapy. Protein Z interacts with the protein Z-related protease inhibitor (ZPI) to accelerate degradation of factor Xa by up to 1000-fold. Deficiency in Protein Z has been variably associated with both thrombosis and bleeding tendencies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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