Thermo Fisher Scientific Alpha-1-Antitrypsin (SERPINA1) Recombinant Rabbit Monoclonal Antibody (AAT, 3167R)
Thermo Fisher의 Alpha-1-Antitrypsin (SERPINA1) 재조합 토끼 단일클론 항체로 인간 시료에 반응합니다. Western blot 및 IHC(P)에서 1–2 µg/mL 농도로 사용 가능하며, 고순도 Protein A/G 정제 및 PBS 버퍼로 제공됩니다. 연구용으로만 사용됩니다.
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- 5265-RBM4-P1
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | AAT, 3167R |
| Immunogen | Recombinant human Alpha-1-Antitrypsin (AAT) protein fragment (amino acids 41–179) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Alpha-1-Antitrypsin (Alpha-1-AT) is synthesized in the liver and functions as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
Deficiency of Alpha-1-AT can lead to chronic obstructive lung disease (emphysema) and, less frequently, hepatic cirrhosis in infants or respiratory distress in newborns.
Alpha-1-AT levels increase as an acute-phase response to tissue necrosis and inflammation, and are elevated in conditions such as rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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