Thermo Fisher Scientific RIPK3 Monoclonal Antibody (OTI3A12), TrueMAB
RIPK3 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 최적화되어 있습니다. Human 시료에 반응하며, Lyophilized 형태로 제공됩니다. 고순도 Affinity chromatography 정제 제품으로, 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 233–518 of human RIPK3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. It contains a unique C-terminal domain distinct from other RIP family members and is predominantly localized in the cytoplasm, often co-localized with mitochondria. RIPK3 participates in the TNF receptor-I signaling complex, can induce apoptosis, and weakly activates NF-kappaB. Caspase-8 prevents RIPK3-dependent necrosis by forming a proteolytically active complex with CFLAR, which is essential for its protective function.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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