Thermo Fisher Scientific Phospho-PTPN11 (Tyr584) Polyclonal Antibody
Phospho-PTPN11 (Tyr584) 폴리클로날 항체로, 인간·생쥐·랫트 시료에서 SHP2 단백질의 인산화 상태를 검출. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용 가능. 단백질 A로 정제된 고순도 항체로 안정적인 신호 검출 제공.
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Thermo Fisher Scientific Phospho-PTPN11 (Tyr584) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat, Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human PTPN11 around the phosphorylation site of Tyr584 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene belongs to the protein tyrosine phosphatase (PTP) family, which regulates numerous cellular processes such as growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains that mediate phospho-tyrosine binding and substrate interaction. It is widely expressed and plays a regulatory role in cell signaling events related to mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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