Thermo Fisher Scientific Phospho-Pyk2 (Tyr881) Polyclonal Antibody
Phospho-Pyk2 (Tyr881) 특이적 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, Protein A로 정제된 고순도 액상 항체입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human Pyk2 around the phosphorylation site of Tyr881 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. PTK2B regulates actin cytoskeleton reorganization, cell polarization, migration, adhesion, spreading, and bone remodeling. It plays a role in the regulation of the humoral immune response and is necessary for normal levels and migration of splenic B-cells. PTK2B functions downstream of integrin, collagen, immune, G-protein coupled, cytokine, chemokine, and growth factor receptors, mediating responses to cellular stress. Aberrant expression may contribute to cancer cell proliferation, migration, and invasion, and elevated expression has been observed in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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