Thermo Fisher Scientific RAB3IP Polyclonal Antibody
RAB3IP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 ELISA에 사용 가능하며, 인간, 생쥐, 랫트 반응성. 액상 형태, 0.2 mg/mL 농도, PBS/glycerol buffer에 보관. 세포 내 위치 및 GEF 기능 연구에 적합.
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Thermo Fisher Scientific RAB3IP Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–150 of human RAB3IP (NP_0719012) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805060 |
Product Specific Information
- Immunogen sequence:
MANDPLEGFH EVNLASPTSP DLLGVYESGT QEQTTSPSVI YRPHPSALSS VPIQANALDV SELPTQPVYS SPRRLNCAEI SSISFHVTDP APCSTSGVTA GLTKLTTRKD NYNAEREFLQ GATITEACDG SDDIFGLSTD SLSRLRSPSV - Positive Samples: 293T
- Cellular Location: Cell projection, Cytoplasm, Nucleus, Cytoskeleton, Lamellipodium
Target Information
RAB3IP is a guanine nucleotide exchange factor (GEF) that activates RAB8A and RAB8B by promoting GDP-to-GTP exchange, converting inactive GDP-bound Rab proteins into their active GTP-bound form. It mediates GDP release from RAB8A and RAB8B, but not from RAB3A or RAB5. RAB3IP modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42, and DNMBP, it promotes transcytosis of PODXL to apical membrane initiation sites (AMIS), apical surface formation, and lumenogenesis.
Additional Information
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-88659_RAB3IP_Q96QF0-1_Rabbit.svg, PA5-88659_RAB3IP_Q96QF0-1_Rabbit_PDP.jpeg)
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