Thermo Fisher Scientific MICA Polyclonal Antibody
Thermo Fisher Scientific의 MICA 폴리클로날 항체는 인간 및 마우스 시료에 반응하며, Western Blot과 ELISA에 적합합니다. 재조합 단백질(aa 24-307)을 면역원으로 사용하였고, 액상 형태로 제공됩니다. 항암 면역 연구 및 MHC 관련 단백질 분석에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 24–307 of human MICA (NP_0002381) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.48 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805062 |
Product Specific Information
- Immunogen sequence:
EPHSLRYNLT VLSWDGSVQS GFLTEVHLDG QPFLRCDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEGLHSL QEIRVCEIHE DNSTRSSQHF YYDGELFLSQ NLETKEWTMP QSSRAQTLAM NVRNFLKEDA MKTKTHYHAM HADCLQELRR YLKSGVVLRR TVPPMVNVTR SEASEGNITV TCRASGFYPW NITLSWRQDG VSLSHDTQQW GDVLPDGNGT YQTWVATRIC QGEEQRFTCY MEHSGNHSTH PVPSGKVLVL QSHW - Positive Samples: K-562, Jurkat
- Cellular Location: Cell membrane, Cytoplasm, Single-pass type I membrane protein
Target Information
Major histocompatibility complex (MHC) class I proteins mediate recognition of intracellular antigens by cytotoxic T cells. The MHC class I chain-related (MIC) proteins, including MICA, are recognized by NKG2D receptors on NK and T cells, promoting anti-tumor activity.
MICA is widely expressed on various tumors and in most normal tissues except the nervous system, suggesting its role in immune-mediated anti-tumor responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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