Thermo Fisher Scientific KCNE1 Polyclonal Antibody
KCNE1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ICC/IF 실험에 적합하며, 인간, 마우스, 랫트 반응성을 가집니다. 고순도 Affinity chromatography 정제, PBS/glycerol 버퍼에 보관되며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KCNE1 (Accession P15382), corresponding to amino acid residues F54–R104 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854536 |
Product Specific Information
Antibody detects endogenous levels of total KCNE1.
Target Information
Kcne1 is a member of voltage-gated potassium (Kv) channels, representing a complex class of ion channels involved in diverse physiological processes such as neurotransmitter release, heart rate regulation, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume control.
The Kcne1 gene encodes a membrane protein similar to KCNE1, part of the voltage-gated potassium channel subfamily. It is an intronless gene deleted in AMME contiguous gene syndrome and may contribute to cardiac and neurological abnormalities associated with that syndrome.
Functionally, Kcne1 acts as an ancillary subunit forming heteromeric complexes with Kv channel alpha subunits, essential for generating native K(+) currents. It also serves as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1.
Diseases associated with KCNE1 include Jervell and Lange-Nielsen Syndrome 2 and Long QT Syndrome 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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