Thermo Fisher Scientific Angiotensin I Converting Enzyme (ACE)/CD143 Monoclonal Antibody (ACE, 3765)
인간 ACE/CD143 단백질을 인식하는 Mouse monoclonal 항체로, Western blot 및 IHC(P)에서 검증됨. 단백질 A/G로 정제된 액상형 제품이며, 보존제 미포함. 혈압 및 체액 균형 조절 관련 연구에 적합.
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- 1636-MSM5-P1ABX
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ACE, 3765 |
| Immunogen | Recombinant fragment (around aa 652–788) of human ACE, CD143 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is tested in direct ELISA.
- For immunohistochemistry (PFA-fixed): incubate antibody for 30 min at room temperature.
- For formalin-fixed tissues, heat sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, then cool at room temperature for 20 min before staining.
Target Information
This gene encodes an enzyme that catalyzes the conversion of angiotensin I into angiotensin II, a potent vasopressor and aldosterone-stimulating peptide regulating blood pressure and fluid-electrolyte balance.
The enzyme plays a key role in the renin-angiotensin system.
Genetic variations, including the presence or absence of a 287 bp Alu repeat, have been linked to circulating enzyme levels and cardiovascular pathophysiologies.
Two major alternatively spliced variants encode somatic and testicular isozymes, both active. Additional splice variants exist but are not fully characterized.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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