Thermo Scientific™

Pierce™ Iodoacetic Acid

Thermo Scientific Pierce Iodoacetic Acid (IAA) can react with several protein functional groups but is typically used for specific S-carboxymethylation자세히 알아보기

Thermo Scientific Pierce Iodoacetic Acid (IAA) can react with several protein functional groups but is typically used for specific S-carboxymethylation of sulfhydryls (reduced cysteines).

Features of Pierce Iodocetic Acid (IAA):

• React at slightly alkaline pH for specific S-carboxymethylation of free sulfhydryls
• React at low pH for specific carboxymethylation of methionines
• React at high pH to favor carboxymethylation of histidines and lysines
• Methylate reduced cysteine peptide fragments in protease digests for mass spectrometry

Iodoacetic acid reacts with sulfhydryls on cysteines, imidazolyl side chain nitrogens of histidines, the thioether of methionine and the primary amine group of lysines.The rate of reaction and specificity is dependent on the ionization level, which can be manipulated by the pH of the reaction condition.

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Pierce™ Iodoacetamide, Single-Use

사양

화학물질 반응성Thiol

설명Iodoacetic Acid

라벨 또는 염료Unreactive Group

라벨 유형Blocking Groups

제품라인Pierce™

스페이서Short (<10 Å)

형태Powder

수량500 mg

용해도Water

제품 유형Iodoacetic Acid

Unit SizeEach