Thermo Fisher Scientific AR Monoclonal Antibody (OTI1D3), TrueMAB
인간 AR 단백질(아미노산 420-659)을 항원으로 제작된 마우스 단일클론 항체. Western blot과 IHC(P)에서 검증됨. 비결합형 액상 형태로 1 mg/mL 농도. PBS/BSA/glycerol 버퍼에 보관하며 -20°C에서 안정적. 연구용으로만 사용 가능.
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Thermo Fisher Scientific AR Monoclonal Antibody (OTI1D3), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 420–659 of human AR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is larger than 90 kDa and contains three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain.
AR acts as a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
The AR signaling pathway is crucial for the development and function of male reproductive organs such as the prostate and epididymis, and also affects nonreproductive tissues including muscle, hair follicles, and brain.
AR is a phosphoprotein that regulates the MAP kinase pathway; inhibition of MEK1/2 correlates with changes in AR phosphorylation.
Abnormal AR signaling is associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in this gene cause complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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