Thermo Fisher Scientific PSTPIP1 Polyclonal Antibody
PSTPIP1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot과 IHC(Paraffin)에 적합하며, 인간, 마우스, 랫트에서 반응합니다. 항원 친화 크로마토그래피로 정제되어 순도 95% 이상을 보장합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific PSTPIP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein of human PSTPIP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719985 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using epitope-specific immunogen by affinity chromatography. Purity is >95% (by SDS-PAGE).
Target Information
PSTPIP1 is involved in regulation of the actin cytoskeleton and may regulate WAS actin-bundling activity. It bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. Acts as a scaffold protein between PTPN12 and WAS, allowing PTPN12 to dephosphorylate WAS. It couples CD2 and CD2AP to WAS, promoting actin polymerization required for synapse induction during T-cell activation. PSTPIP1 also plays a role in innate immunity and inflammatory response, recruited to inflammasomes by MEFV, inducing formation of pyroptosomes composed of oligomerized PYCARD dimers prior to inflammatory apoptosis. Binding to MEFV facilitates PYCARD interaction and pyroptosome formation. It regulates endocytosis and cell migration in neutrophils.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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