Thermo Fisher Scientific p130 Monoclonal Antibody (KAB40)
p130 단백질의 인산화 및 비인산화 형태 모두를 인식하는 단클론 항체로, Western blot 분석에 적합합니다. Human, Mouse, Rat 시료에 반응하며 Protein A/G로 정제된 액상 형태입니다. 세포 분열 조절 및 크로마틴 구조 연구에 유용합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | KAB40 |
| Immunogen | GST fusion protein to the N terminus of p130 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A/G |
| Storage buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1077383 |
Product Specific Information
This antibody recognizes both the phosphorylated and unphosphorylated forms of p130 at a molecular weight of 130 kDa. It is suitable for use in Western blot with His-tagged or GST-tagged proteins.
Target Information
RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure, particularly that of constitutive heterochromatin, by stabilizing histone methylation.
RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. It controls histone H4 Lys20 trimethylation and likely acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters.
RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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