Thermo Fisher Scientific RCN3 Polyclonal Antibody
RCN3 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 적합. Human 시료 반응성. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RCN3. Recombinant protein control fragment (Product #RP-103074). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.30 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646434 |
Product Specific Information
Immunogen sequence:
EFPHMRDIVI AETLEDLDRN KDGYVQVEEY IADLYSAEPG EEEPAWVQTE RQQFRDFRDL
Highest antigen sequence identity to the following orthologs:
- Mouse: 93%
- Rat: 97%
Target Information
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891).
Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D, and the lipid transporter ABCA3.
By regulating both the proper expression and degradation through the endoplasmic reticulum-associated protein degradation pathway, it plays a crucial role in pulmonary surfactant homeostasis.
Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891).
This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634).
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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