Thermo Fisher Scientific FBXL20 Polyclonal Antibody
Rabbit polyclonal antibody against human FBXL20. Validated for WB and ICC/IF applications. Antigen affinity purified and supplied in PBS with glycerol. Suitable for protein expression and localization studies. For research use only.
- 카탈로그번호
- PA562180
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific FBXL20 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FBXL20. Recombinant protein control fragment (Product # RP-100021) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641533 |
Product Specific Information
Immunogen sequence:
IGAHCPELVT LNLQTCLQIT DEGLIT
Highest antigen sequence identity to orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS, and abundant at presynaptic membranes. It has orthologs in C. elegans, D. melanogaster, and mammals, suggesting a conserved role as a membrane-localized E3 ligase. Scrapper regulates synaptic transmission via degradation of RIM1a through the ubiquitin-proteasome system (UPS), highlighting protein degradation as a mechanism for maintaining synaptic communication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.