Thermo Fisher Scientific CaV1.2a Polyclonal Antibody
Rabbit polyclonal antibody against CaV1.2a for WB, IHC, ICC/IF, and IP applications. Targets the alpha-1 subunit of voltage-dependent calcium channels. Supplied lyophilized, reconstitute with 50 µL water. Storage at -20°C. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution / Condition |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | GST fusion protein with residues 1–46 of rabbit CaV1.2a, with serine 44 replaced with alanine |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.95 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735584 |
Product Specific Information
- Shipped at room temperature as a lyophilized powder.
- Store at -20°C upon receipt.
- Reconstitution: Add 50 µL of deionized water.
Target Information
CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. These channels mediate calcium ion influx upon membrane polarization. The alpha-1 subunit, containing 24 transmembrane segments, forms the ion-conducting pore. The calcium channel complex consists of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Multiple isoforms exist due to gene diversity and alternative splicing. The CACNA1C protein binds to and is inhibited by dihydropyridine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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