Thermo Fisher Scientific CYP2E1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 234-493 of human CYP2E1 (NP_000764.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CYP2E1,uniProtId:P05181-1,ncbiNodeId:9606,antigenRange:234-493,antigenLength:493,antigenImageFileName:PA5-120794_CYP2E1_P05181-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120794_CYP2E1_P05181-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.32 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914366

Product Specific Information

Positive test controls include: Mouse liver, Mouse kidney, Rat liver. The target is usually found in the following locations: Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein.

Immunogen sequence: KVIKNVAEVK EYVSERVKEH HQSLDPNCPR DLTDCLLVEM EKEKHSAERL YTMDGITVTV ADLFFAGTET TSTTLRYGLL ILMKYPEIEE KLHEEIDRVI GPSRIPAIKD RQEMPYMDAV VHEIQRFITL VPSNLPHEAT RDTIFRGYLI PKGTVVVPTL DSVLYDNQEF PDPEKFKPEH FLNENGKFKY SDYFKPFSTG KRVCAGEGLA RMELFLLLCA ILQHFNLKPL VDPKDIDLSP IHIGFGCIPP RYKLCVIPRS

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.