Thermo Fisher Scientific IRF3 Polyclonal Antibody
IRF3 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, IP 등 다양한 응용에 적합합니다. 세포질 및 핵 내 IRF3 검출에 사용되며, 0.61 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 - 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 - 1:200 |
| Immunocytochemistry (ICC/IF) | 1:50 - 1:200 |
| Immunoprecipitation (IP) | 1:50 - 1:200 |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 100–200 of human IRF3 (NP_001184051.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.61 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914367 |
Product Specific Information
Positive test controls include mouse brain and rat brain.
The target is typically localized in the cytoplasm and nucleus.
Target Information
IRF3 (Interferon Regulatory Factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IRF3 regulates transcription of IFN-alpha, IFN-beta, and interferon-stimulated genes (ISG) by binding to the interferon-stimulated response element (ISRE) in their promoters.
Upon viral infection or toll-like receptor signaling, IRF3 becomes phosphorylated by IKBKE and TBK1, leading to dimerization, nuclear localization, and activation of type I IFN and ISG gene transcription.
Mutations in the IRF3 gene can cause acute infection-induced encephalopathy (herpes-specific type 7).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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