Thermo Fisher Scientific UBASH3A Polyclonal Antibody
UBASH3A 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot 및 IHC(Paraffin)에서 검증됨. 인간 반응성, 액상 형태, 0.5 mg/mL 농도. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
Immunohistochemistry (Paraffin) (IHC (P))
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (QQCSTPDGKYYRPD) corresponding to internal amino acids of UBASH3A (aa 417–431) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_10985821 |
Product Specific Information
- Predicted to react with canine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), also known as STS-2 or CLIP4, is a 661 amino acid protein localized in both the nucleus and cytoplasm. It contains one SH3 domain and one UBA domain and is highly expressed in thymus, bone marrow, spleen, and peripheral blood leukocytes.
TULA forms homodimers or homo-oligomers that interfere with receptor-type tyrosine kinase degradation, promoting accumulation of activated receptors on the cell surface. It is part of an EGFR- and Cbl-containing complex interacting with ubiquitinated proteins.
The gene encoding TULA maps to human chromosome 21 and may be involved in the pathogenesis of type I diabetes. Multiple isoforms are produced via alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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