Thermo Fisher Scientific ATF2 Polyclonal Antibody
ATF2 단백질을 인식하는 염소 유래 다클론 항체로 Western blot에 적합합니다. 인간에 반응하며, 소·개·쥐에서도 예측 반응성을 보입니다. 0.5 mg/mL 농도의 액상 형태로 제공되며, TBS(pH 7.3)와 0.5% BSA를 포함합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C terminus amino acids IVMAPSSQSQPSGS (aa 492–505) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_1070500 |
Product Specific Information
- Predicted to react with bovine, canine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
The transcription factor ATF-2 (also known as CRE-BP1) binds to both AP-1 and CRE DNA response elements and belongs to the ATF/CREB family of leucine zipper proteins.
ATF-2 interacts with viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways.
Various forms of cellular stress—such as genotoxic agents, inflammatory cytokines, and UV irradiation—stimulate ATF-2 transcriptional activity.
Activation occurs via phosphorylation at Thr69 and Thr71, mediated by SAPK and p38 MAPK both in vitro and in transfected cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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