Thermo Fisher Scientific IP3 Receptor 1 Polyclonal Antibody
IP3 Receptor 1을 인식하는 Rabbit Polyclonal Antibody로 다양한 종에 반응. WB, IHC, ICC/IF 등 여러 응용에 사용 가능. 고순도 항원 친화 크로마토그래피 정제 제품으로 안정적인 액상 형태 제공. 연구용으로 ER 내 칼슘 신호 조절 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 22 publications |
| Immunohistochemistry (IHC) | - | View 9 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:250 | View 2 publications |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 8 publications |
| Flow Cytometry (Flow) | - | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Published Species | Hamster, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptide: N(1829) K K K D D E V D R D A P S R K K A K E(1848) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2129984 |
Product Specific Information
PA1-901 detects inositol 1,4,5-trisphosphate receptor type-I (IP3R-I) from canine, mouse, and rat tissues.
It has been successfully used in Western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation procedures.
By Western blot, this antibody detects an ~240 kDa protein representing IP3R-I from rat and mouse brain extract.
Immunohistochemical staining of IP3R-I in rat cerebellum results in staining of Purkinje cells.
The immunizing peptide corresponds to amino acid residues 1829–1848 from human IP3R-I, which are completely conserved in human, mouse, and rat.
The peptide (Cat. # PEP-019) is available for neutralization and control experiments.
Target Information
Intracellular channel mediating calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.
Involved in regulating epithelial secretion of electrolytes and fluid via interaction with AHCYL1.
Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER activates CaM kinase II, leading to downstream apoptosis pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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