Thermo Fisher Scientific CD268 (BAFF Receptor) Monoclonal Antibody (eBio7H22-E16), APC, eBioscience

Thermo Fisher Scientific CD268 (BAFF Receptor) Monoclonal Antibody (eBio7H22-E16), APC, eBioscience

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 0.25 µg/test
  View 3 publications

Product Specifications

Additional Formats:

• FITC
• Request custom conjugation

Product Specific Information

The monoclonal antibody eBio7H22.E16 reacts with mouse BAFF-Receptor (CD268), a type III transmembrane TNF receptor family member.
BAFF-R is predominantly expressed on peripheral B cells in both humans and mice, found on the surface of all B220+ B cells in the spleen.
It is also expressed on activated/memory T-cell subsets and plays a critical role in splenic B cell maturation and survival, mediating BAFF-dependent costimulatory responses in peripheral B and T cells.
Defects in BAFF-R can lead to decreased mature B-cell generation and autoimmune disorders. The ligand for BAFF-R is BAFF (BLyS).

Applications Reported:
This antibody is reported for use in flow cytometric analysis.

Applications Tested:
Validated in flow cytometric analysis of mouse splenocytes at ≤0.25 µg/test (100 µL final volume).
Cell number may vary from 10⁵ to 10⁸ cells/test. Antibody titration is recommended for optimal assay performance.
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Post-manufacturing filtered with 0.2 µm filter.

Target Information

Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), also known as BAFFR, is encoded by the TNFRSF13C gene located on chromosome 22q13.1–q13.31.
It encodes a 184-amino-acid transmembrane protein, 56% identical to the mouse protein.
BAFF enhances B-cell survival and regulates peripheral B-cell populations, playing a crucial role in B-cell development and functioning through receptors such as BCMA.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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