Thermo Fisher Scientific Sirt1 Polyclonal Antibody
SIRT1 단백질을 표적하는 Rabbit Polyclonal 항체로 Western Blot 및 Immunoprecipitation에 적합. NAD-의존성 탈아세틸화 효소 연구에 활용 가능. 액상 형태로 제공되며 4°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 1–4 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25 and 75 of Human Sirtuin (Silent Mating Type Information Regulation 2) type 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis, and autophagy.
SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression.
It is essential in skeletal muscle cell differentiation and, in response to low nutrients, mediates the inhibitory effect on skeletal myoblast differentiation involving 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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