Thermo Fisher Scientific PCCA Monoclonal Antibody (OTI1E9), TrueMAB
PCCA 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 IHC(P)에서 사용 가능. 인간, 마우스, 랫트 반응성. 동결건조 형태로 제공되며, PBS/trehalose buffer에 용해 가능. 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E9 |
| Immunogen | Full length human recombinant protein of human PCCA produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
PCCA is a key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine.
It likely forms a dodecamer composed of six biotin-containing alpha subunits and six beta subunits, located in the mitochondrial matrix.
Defects in PCCA cause propionic acidemia type I (PA-1), a life-threatening disorder characterized by:
- Episodic vomiting, lethargy, and ketosis
- Neutropenia and periodic thrombocytopenia
- Hypogammaglobulinemia and developmental retardation
- Intolerance to protein
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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