Thermo Fisher Scientific MERTK Monoclonal Antibody (A311F9G3)
인간 MERTK 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 Flow cytometry에 사용 가능. 단백질 G로 정제된 액상 형태이며, PBS와 0.1% sodium azide를 포함. 세포 생존, 이동, 분화 및 식세포 작용 연구에 적합.
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Applications
- Western Blot (WB): 1:1,000
- Flow Cytometry (Flow): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A311F9G3 |
| Immunogen | Human MERTK extracellular domain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539411 |
Product Specific Information
This target has a predicted molecular weight of 110 kDa.
Target Information
MERTK (cMER) is a tyrosine kinase proto-oncogene involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease.
It regulates physiological processes including cell survival, migration, differentiation, and efferocytosis (phagocytosis of apoptotic cells).
Ligand binding induces autophosphorylation of MERTK, creating docking sites for downstream signaling molecules.
Upon activation, MERTK interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1.
MERTK signaling contributes to macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and engulfment.
In RPE, it regulates rod outer segment fragment phagocytosis and inhibits Toll-like receptor (TLR)-mediated innate immune responses by activating STAT1, which induces SOCS1 and SOCS3 production.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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