Thermo Fisher Scientific MASTL Polyclonal Antibody
MASTL 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 적합합니다. 고순도 액상 형태이며 4°C 보관, 1년 권장 보관 기간을 가집니다. 세포주기 및 암 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 550 and 600 of human microtubule associated serine/threonine kinase-like (MASTL, UniProt ID: Q96GX5-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
MASTL (microtubule associated serine/threonine kinase-like) belongs to the MAST family within the AGC Ser/Thr protein kinase group. It promotes mitotic progression and cell cycle reentry after DNA damage. Loss of MASTL leads to defects in chromosome condensation and separation, primarily mediated by inhibition of PP2A/B55 delta. Overexpression of MASTL is associated with cancer progression, poor survival, and tumor recurrence. Mutations at this locus are linked to autosomal dominant thrombocytopenia (thrombocytopenia-2). Alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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