Thermo Fisher Scientific MAST2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

Syntrophin is an adapter protein that binds signaling molecules to the dystrophin-associated protein complex, which connects the extracellular matrix to the intracellular cytoskeleton, maintaining postsynaptic structures in the neuromuscular junction and central nervous system.

Microtubule-associated serine/threonine-protein kinase 2 (MAST205) is a testis-specific, cytoplasmic protein functioning in a multi-protein complex during spermatid maturation. MAST205 links the dystrophin/utrophin network with microtubule filaments via syntrophin. By forming a complex with TRAF6, MAST205 regulates lipopolysaccharide-induced IL-12 synthesis in macrophages, inhibiting TRAF6 NF-kappa-B activation.

Two isoforms exist for MAST205 due to alternative splicing:

• Isoform 1: full-length protein
• Isoform 2: lacks residues 327–396 and 1091–1113

Phosphorylation at the N-terminus is required for ubiquitination at the same site, leading to proteasome-mediated degradation of MAST205.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.