Thermo Fisher Scientific PIMT Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Target Information

Catalyzes the two serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, colocalization with coilin, and formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.