Thermo Fisher Scientific WNK1 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 WNK1 단백질 인식 폴리클로날 항체. Western blot 및 Immunocytochemistry에 사용 가능. 항원 친화 크로마토그래피로 정제된 5 mg/mL 액상 형태. 혈압 및 이온 수송 조절 연구에 적합.
- 카탈로그번호
- PA116871
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide sequence within the C-terminal region of human WNK1 (within the last 350 amino acids). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_568773 |
Product Specific Information
- In Western blot, this antibody recognizes the short form of WNK1 (~190 kDa).
- The theoretical molecular weight of human WNK1 is approximately 251 kDa, and rat WNK1 is approximately 230 kDa.
Target Information
WNK1 serine/threonine kinase is a member of the WNK subfamily. WNK1 may regulate blood pressure by controlling sodium and chloride ion transport. Mutations in this gene are associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II.
WNK1 plays an important role in electrolyte homeostasis, cell signaling, survival, and proliferation. It acts as both an activator and inhibitor of sodium- and potassium-coupled chloride cotransporters, respectively. WNK1 activates SCNN1A, SCNN1B, SCNN1D, and SGK1, and localizes to the distal nephron, involved in salt, potassium, and pH regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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