Thermo Fisher Scientific RIPK1 Monoclonal Antibody (OTI2F1), TrueMAB
인간 RIPK1 단백질(aa 133-422)을 인식하는 Mouse IgG1 단클론 항체입니다. Western blot에 1:500 희석으로 검증되었으며, 액상 형태로 제공됩니다. PBS/BSA/glycerol 버퍼에 보관하며, -20°C에서 안정적으로 유지됩니다. 염증 및 세포사멸 신호전달 연구용으로 적합합니다.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 133–422 of human RIPK1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptor ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at Ser-728 in a TNF-alpha-dependent manner, activating the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via Lys-63-linked chains enhances communication with downstream transducers in the MAPK and NF-kappa-B pathways, mediating activation of inflammatory genes. Polyubiquitinated protein binds to IKBKG/NEMO, essential for NF-kappa-B activation. RIPK1 interacts with RHIM-containing adapters to initiate gene activation and cell death; association with RIPK3 forms a necrosis-inducing complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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