Thermo Fisher Scientific USP15 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
IFAMDENLSS IMERDDIYVF EININRTEDT EHVIIPVCLR EKFRHSSYTH HTGSSLFGQP FLMAVPRNNT EDKLYNLLLL RMCRYVKIST ETEETEGSLH CCKDQNINGN GPNGIHEEGS PSEMETD

Target Information

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. Deubiquitination is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families:

1. Ubiquitin C-terminal hydrolases
2. Ubiquitin-specific processing proteases (USPs)
3. OTU-domain ubiquitin-aldehyde-binding proteins
4. Jab1/Pad1/MPN-domain-containing metallo-enzymes

Among these, USPs are the most widespread deubiquitinating enzymes across evolution. They release ubiquitin from conjugated proteins and contain conserved Cys and His catalytic domains, with variable terminal extensions that aid in substrate recognition, localization, and protein interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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