ELK Biotechnology PKD2 rabbit pAb
PKD2 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 세포질, 세포막, 핵, 골지체에서 발현. 합성 펩타이드 항원으로 제작, 고순도 IgG 1 mg/ml 농도.
- 판매단위
- pk
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ELK Biotechnology PKD2 rabbit pAb
제품 설명
PKD2 rabbit pAb는 인간 PKD2 단백질을 인식하는 고품질 토끼 폴리클로날 항체입니다. 이 항체는 다양한 응용 분야(WB, IHC, IF, ELISA)에 적합하며, 세포 내 PKD2 단백질의 발현 및 위치 분석에 유용합니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product Name | PKD2 rabbit pAb |
| Alternative Names | PRKD2; PKD2; HSPC187; Serine/threonine-protein kinase D2; nPKC-D2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/5000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human PKD2 (AA range: 829–878) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 96 kDa |
| Gene ID (Human) | 25865 |
| Human Swiss-Prot No. | Q9BZL6 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, Cell membrane, Nucleus, Golgi apparatus (trans-Golgi network). Translocation to the cell membrane is required for kinase activation. Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. |
Background
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.
[Provided by RefSeq, Jul 2008]
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