Thermo Fisher Scientific GARP Monoclonal Antibody (G14D9), PE, eBioscience

Thermo Fisher Scientific GARP Monoclonal Antibody (G14D9), PE, eBioscience™

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (0.5 µg)/test
Publications: View 4 publications

Product Specifications

Additional Formats

• eFluor 660
• FITC
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 600
• Super Bright 702
• Request custom conjugation

Product Specific Information

The G14D9 monoclonal antibody reacts with human Glycoprotein A Repetitions Predominant (GARP, also known as LRRC32 or Garpin).
GARP is an approximately 80 kDa glycoprotein expressed on the cell surface. Expression is reported in placenta, lung, kidney, heart, ovary, liver, skeletal muscle, and pancreas, and observed on megakaryocytes, platelets, and activated regulatory T (Treg) cells.
Surface GARP expression on activated Treg cells is required for suppressive function, possibly acting as a receptor for LAP/TGF beta.

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested with stimulated normal human peripheral blood cells; use 5 µL (0.5 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).
Excitation: 488–561 nm
Emission: 578 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered

Target Information

GARP (leucine rich repeat containing 32) is a type I membrane protein with 22 leucine-rich repeats and a short cytoplasmic region.
It was identified through gene expression profiling of Treg and Th cells following TCR stimulation.
Expressed in CD4⁺, CD25⁺, FoxP3⁺ (Treg) cells, GARP is a candidate surface marker for Treg identification.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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