Thermo Fisher Scientific Gemtuzumab Recombinant Human Monoclonal Antibody (hP67.6 (Gemtuzumab))
인간 CD33 항원을 인식하는 재조합 인간 단일클론 항체로, HEK293 세포에서 발현된 IgG4 kappa 형식입니다. 단백질 A로 정제되었으며, PBS 버퍼에 0.02% ProClin 300을 포함합니다. 면역세포 표지 및 세포 분석 연구용으로 적합합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG4, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | hP67.6 (Gemtuzumab) |
| Immunogen | Gemtuzumab was generated by humanization of the murine P67.6 clone, raised against CD33-transfected FMY9S5 cells of human origin. CD33 is a transmembrane receptor expressed predominantly on cells of the myeloid lineage, but also found on some lymphoid cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Recognises human CD33.
Target Information
Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody conjugated with a calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from Micromonospora echinospora ssp. calichensis. Approximately 50% of the antibody is loaded with 4–6 moles of calicheamicin per mole of antibody.
The antibody specifically binds to the CD33 antigen present on leukemic myeloblasts in most patients with acute myeloid leukemia (AML). By binding to CD33, the cytotoxic agent inhibits tumor cell growth and induces apoptosis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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