Thermo Fisher Scientific Tau Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and mouse.
• Specificity: Tau protein.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
Tau localization determines axonal polarity in neurons. Short isoforms provide cytoskeletal plasticity, while long isoforms contribute to stabilization.
In its hyper-phosphorylated form, Tau is a major component of paired helical filaments (PHF), which form neurofibrillary lesions in Alzheimer’s disease.
Hyper-phosphorylation impairs microtubule binding, leading to neuronal degeneration.
Tau phosphorylation involves kinases including GSK-3β, PKA, CDK5, and casein kinase II.
Abnormal Tau is associated with Alzheimer’s disease, Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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