Thermo Fisher Scientific PGRPS Polyclonal Antibody
Thermo Fisher Scientific의 PGRPS Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 다양한 면역학적 분석(WB, IHC, ICC, ELISA)에 사용됩니다. KLH 결합 합성 펩타이드 면역원으로 제작되었으며, 고순도 Protein A 정제 및 안정적인 저장 조건을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human PGRPS, amino acids 65–150 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), elicit immune reactions ranging from cytokine release to fever. A family of proteins called peptidoglycan recognition proteins (PGRPs) has been identified in mouse and human that bind to peptidoglycans expressed on Gram-positive bacteria.
Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and serves as a key target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules.
- PGRP-L is primarily expressed in the liver and contributes to host defense by producing acute phase proteins and clearing microorganisms from blood.
- PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria, functioning as a neutrophil antibacterial protein. It is also expressed in bone marrow at much higher levels than in neutrophils, suggesting additional roles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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