Thermo Fisher Scientific PGRPS Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), elicit immune reactions ranging from cytokine release to fever. A family of proteins called peptidoglycan recognition proteins (PGRPs) has been identified in mouse and human that bind to peptidoglycans expressed on Gram-positive bacteria.

Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and serves as a key target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules.

• PGRP-L is primarily expressed in the liver and contributes to host defense by producing acute phase proteins and clearing microorganisms from blood.
• PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria, functioning as a neutrophil antibacterial protein. It is also expressed in bone marrow at much higher levels than in neutrophils, suggesting additional roles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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