Thermo Fisher Scientific C-Myc Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK has been linked to cell cycle regulation.

c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated c-Myc expression induces apoptosis and contributes to neoplastic transformation. Antibodies against c-Myc recognize Myc-tagged recombinant proteins and are widely used in molecular and cancer research.

Amplification of the c-Myc gene is observed in lung, breast, and colon carcinomas, while N-Myc amplification is common in neuroblastomas. Translocation of the c-myc locus to immunoglobulin loci is characteristic of Burkitt’s lymphoma and other B-cell malignancies. Aberrant c-Myc expression occurs in tumors across multiple tissues including gastrointestinal, hepatic, mammary, ovarian, and hematopoietic origins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.