Thermo Fisher Scientific C-Myc Polyclonal Antibody
Thermo Fisher Scientific의 C-Myc Polyclonal Antibody는 인간 및 고양이, 영장류 시료에서 c-Myc 단백질 검출에 적합합니다. Western blot, ELISA, IP 등에 사용 가능하며, rabbit IgG 폴리클로날 항체로 Affinity chromatography로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cat, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 400–454 of human c-Myc protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK has been linked to cell cycle regulation.
c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated c-Myc expression induces apoptosis and contributes to neoplastic transformation. Antibodies against c-Myc recognize Myc-tagged recombinant proteins and are widely used in molecular and cancer research.
Amplification of the c-Myc gene is observed in lung, breast, and colon carcinomas, while N-Myc amplification is common in neuroblastomas. Translocation of the c-myc locus to immunoglobulin loci is characteristic of Burkitt’s lymphoma and other B-cell malignancies. Aberrant c-Myc expression occurs in tumors across multiple tissues including gastrointestinal, hepatic, mammary, ovarian, and hematopoietic origins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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