Thermo Fisher Scientific C-Myc Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with regulation of these processes.

c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated c-Myc expression can induce apoptosis and contribute to oncogenesis. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either the amino or carboxy terminus of target proteins.

Amplification of the c-Myc gene has been observed in multiple human tumors, including lung, breast, and colon carcinomas. N-Myc amplification is associated with neuroblastomas. Chromosomal translocations involving the c-Myc locus are characteristic of Burkitt’s lymphoma and other B-cell proliferative disorders. Aberrant c-Myc expression has also been documented in colorectal, gastric, hepatic, mammary, ovarian, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.