Thermo Fisher Scientific C-Myc Polyclonal Antibody
Rabbit polyclonal antibody recognizing c-Myc protein. Validated for WB, ELISA, and IP applications. Detects human, cat, and non-human primate samples. Affinity purified, liquid form, stored at -20°C. For research use only.
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- CMYC-101AP
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Cat, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 200–250 of human c-Myc protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA and 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with regulation of these processes.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated c-Myc expression can induce apoptosis and contribute to oncogenesis. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either the amino or carboxy terminus of target proteins.
Amplification of the c-Myc gene has been observed in multiple human tumors, including lung, breast, and colon carcinomas. N-Myc amplification is associated with neuroblastomas. Chromosomal translocations involving the c-Myc locus are characteristic of Burkitt’s lymphoma and other B-cell proliferative disorders. Aberrant c-Myc expression has also been documented in colorectal, gastric, hepatic, mammary, ovarian, and hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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