Thermo Fisher Scientific CD104 Recombinant Rabbit Monoclonal Antibody (ARC1046)

Applications

• Western Blot (WB): 1:500–1:1,000
• ELISA: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
SQEGWGRERE GVITIESQVH PQSPLCPLPG SAFTLSTPSA PGPLVFTALS PDSLQLSWER PRRPNGDIVG YLVTCEMAQG GGPATAFRVD GDSPESRLTV PGLSENVPYK FKVQARTTEG FGPEREGIIT IESQDGGPFP QLGSRAGLFQ HPLQSEYSSI TTTHTSATEP FLVDGLTLGA QHLEAGGSLT RHVTQEFVSR TLTTSGTLST HMDQQFFQT

Target Information

Integrins are heterodimers composed of alpha and beta subunits that form noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides create complexes with varying ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion and transduce signals regulating gene expression and cell growth.
The ITGB4 gene encodes the integrin beta 4 subunit, a receptor for laminins, which associates with the alpha 6 subunit and plays a key role in invasive carcinoma biology. Mutations in this gene are linked to epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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