Thermo Fisher Scientific ACE2 Recombinant Rabbit Monoclonal Antibody (ARC1051)
ACE2 단백질을 표적하는 Thermo Fisher의 재조합 토끼 단클론 항체로, WB, IHC, ICC/IF에 사용 가능. 고순도 HEK293 발현 시스템 기반, 1.85 mg/mL 농도. 심혈관 및 바이러스 연구용으로 적합하며, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| Specification | Details |
|---|---|
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5X5W10 |
| Immunogen | A recombinant fusion protein containing a sequence corresponding to amino acids 18–740 of human ACE2. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.85 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2849444 |
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently, ACE2 has also been shown to be a functional receptor of the SARS coronavirus.
The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. Lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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