Thermo Fisher Scientific Human TANK Synthetic Peptide
인간 TANK 단백질의 C-말단 14개 아미노산 서열에 해당하는 합성 펩타이드. PA5-20270 항체의 차단 펩타이드로 사용 가능. NF-κB 신호전달 연구용. 액상 형태, 200 µg/mL 농도, -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the carboxy terminus of human TANK.
PEP-0385 can be used as a blocking peptide with polyclonal antibody PA5-20270.
Target Information
TANK was initially identified as a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families leads to the formation of a TRAF/TANK complex that mediates activation of the transcription factor NF-kappa-B. This occurs through association with kinases IKK-iota and TBK1. These proteins can form a complex with NEMO, which regulates the Ikappa-B complex. This suggests that TBK1 and IKK-iota may activate IKKs and modulate NF-kappa-B transactivation potential. At least two isoforms of TANK are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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