Thermo Fisher Scientific Human TIP47 Synthetic Peptide
Human TIP47 단백질의 C-말단 14개 아미노산 서열로 구성된 합성 펩타이드. TIP47 항체(PA5-20272) 차단용으로 사용 가능. 인간 유래 단백질 연구에 적합하며, PBS(pH 7.2)와 0.1% BSA 용액에 보관. -20°C에서 안정적으로 저장 가능.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the carboxy terminus of human TIP47.
PEP-0387 can be used as a blocking peptide with polyclonal antibody PA5-20272.
Target Information
TIP47 is a cargo protein involved in trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolases from the Golgi to endosomes and then return to the Golgi complex.
The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome-to-Golgi transport.
This protein also binds directly to the GTPase RAB9, a member of the RAS oncogene family, increasing its affinity for cargo. TIP47 has been localized in milk fat globule membranes of human and bovine origin and described as a placental protein.
Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients, suggesting potential significance as an oncodevelopmental marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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