Thermo Fisher Scientific CYP4F3 Polyclonal Antibody
CYP4F3 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 인간 시료에 반응하며, Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관되며, -20°C에서 안정적.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CYP4F3 (Accession Q08477), corresponding to amino acid residues G65–A115 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852740 |
Product Specific Information
This antibody detects endogenous levels of total Cytochrome P450 4F3.
Target Information
Cytochrome P450 superfamily proteins are monooxygenases that catalyze various biochemical reactions involved in drug metabolism and the synthesis of cholesterol, steroids, and lipids.
CYP4F3, a 60 kDa protein, is a member of this family with a conserved heme-binding domain near the C-terminus. It catalyzes the ω-hydroxylation of LTB4 and is localized in the endoplasmic reticulum, playing a vital role in LTB4 inactivation and inflammation control.
CYP4F3 exists in two functionally distinct isoforms:
- CYP4F3A: A neutrophil isoform expressed in neutrophils and myeloid cells; catalyzes microsomal ω-hydroxylation of LTB4 and interacts with CD11b and myeloperoxidase to regulate cellular development in bone marrow.
- CYP4F3B: A liver isoform that converts arachidonic acid to 20-HETE, a potent PKC activator involved in cell proliferation, vascular tone, and natriuresis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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