Thermo Fisher Scientific Claudin 4 Polyclonal Antibody
Claudin-4 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 WB 등 다양한 응용에 사용 가능. Human 및 Mouse 시료에 반응하며, 합성 펩타이드(C-말단 유래)를 면역원으로 제작. 액상 형태, 2 mg/mL 농도, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Published species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the C-terminus of human Claudin-4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10978522 |
Product Specific Information
PA5-16875 targets Claudin 4 in IHC (P) applications and shows reactivity with human and mouse samples.
The PA5-16875 immunogen is a synthetic peptide derived from the C-terminus of human Claudin-4.
Target Information
Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns and are essential components of tight junction charge-specific channels that regulate paracellular ion flux.
Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. Overexpression of Claudin-4 decreases paracellular electrical conductance due to a selective decrease in Na⁺ permeability, with no significant decrease in Cl⁻ permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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