Thermo Fisher Scientific KCNN3 Recombinant Rabbit Monoclonal Antibody (7I9R3)

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7I9R3

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 630-730 of human KCNN3/SK3. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:KCNN3,uniProtId:Q9UGI6-1,ncbiNodeId:9606,antigenRange:630-730,antigenLength:731,antigenImageFileName:MA5-55478_KCNN3_Q9UGI6-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55478_KCNN3_Q9UGI6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.55 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: DLSKMQNVMY DLITELNDRS EDLEKQIGSL ESKLEHLTAS FNSLPLLIAD TLRQQQQQLL SAIIEARGVS VAVGTTHTPI SDSPIGVSST SFPTPYTSSS S

Target Information

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.