Thermo Fisher Scientific IPO5 Recombinant Rabbit Monoclonal Antibody (10K10W2)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:10,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

10K10W2

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human Karyopherin beta3 (IPO5). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IPO5,uniProtId:O00410-1,ncbiNodeId:9606,antigenRange:20-300,antigenLength:1097,antigenImageFileName:MA5-55477_IPO5_O00410-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55477_IPO5_O00410-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.99 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: SPDNVVRKQA EETYENIPGQ SKITFLLQAI RNTTAAEEAR QMAAVLLRRL LSSAFDEVYP ALPSDVQTAI KSELLMIIQM ETQSSMRKKV CDIAAELARN LIDEDGNNQW PEGLKFLFDS VSSQNVGLRE AALHIFWNFP GIFGNQQQHY LDVIKRMLVQ CMQDQEHPSI RTLSARATAA FILANEHNVA LFKHFADLLP GFLQAVNDSC YQNDDSVLKS LVEIADTVPK YLRPHLEATL QLSLKLCGDT SLNNMQRQLA LEVIVTLSET AAAMLRKHTN I

Target Information

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.