Thermo Fisher Scientific IPO5 Recombinant Rabbit Monoclonal Antibody (10K10W2)

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen Sequence:
SPDNVVRKQA EETYENIPGQ SKITFLLQAI RNTTAAEEAR QMAAVLLRRL LSSAFDEVYP ALPSDVQTAI KSELLMIIQM ETQSSMRKKV CDIAAELARN LIDEDGNNQW PEGLKFLFDS VSSQNVGLRE AALHIFWNFP GIFGNQQQHY LDVIKRMLVQ CMQDQEHPSI RTLSARATAA FILANEHNVA LFKHFADLLP GFLQAVNDSC YQNDDSVLKS LVEIADTVPK YLRPHLEATL QLSLKLCGDT SLNNMQRQLA LEVIVTLSET AAAMLRKHTN I

Target Information

Nucleocytoplasmic transport is a signal- and energy-dependent process occurring through nuclear pore complexes in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits (karyopherins). Importin alpha binds the NLS-containing cargo in the cytoplasm, while importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and Ran GTPase, the complex translocates into the nucleus, where importin subunits dissociate. Importin alpha enters the nucleoplasm with its cargo protein, and importin beta remains at the pore. Interactions between importin beta and FG repeats of nucleoporins are essential for translocation through the pore complex. The encoded protein belongs to the importin beta family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.