Thermo Fisher Scientific CDKN2A Monoclonal Antibody (OTI1F10), TrueMAB
CDKN2A 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체입니다. Western blot에 적합하며 인간 시료에 반응합니다. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다. 세포주기 조절 및 종양 억제 연구에 유용합니다.
- 카탈로그번호
- CF805403
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:200–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F10 |
| Immunogen | Full length human recombinant protein of human CDKN2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The CDKN2A gene produces multiple transcript variants differing in their first exons.
Two variants encode isoforms that inhibit CDK4 kinase, while another variant encodes the ARF protein, which stabilizes tumor suppressor p53 by sequestering MDM2.
Despite structural differences, these proteins share a common role in regulating G1 cell cycle progression.
CDKN2A is frequently mutated or deleted in various tumors and functions as an important tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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